Transplantation. Jul 27;66(2) Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients. Minghelli G(1). This agent promotes uric acid excretion via effects on the organic anion transport The AIIA losartan also produces a uricosuric effect in healthy volunteers. Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act.

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Safety of losartan in hypertensive uricosric with thiazide-induced hyperuricemia. Drugs with other primary uses, that have known uricosuric properties, include losartan[1] atorvastatinand fenofibrate.

Table 2 shows the effect of benzbromarone and losartan on the renal excretion of urate in four hypouricemic hypertensive patients harboring URAT1 mutations hypertensive case nos. Lipid exchange at ER-mitochondria contact sites: Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule. A total of eight studies met the inclusion criteria.

Gout and its comorbidities.

However, only two of the studies evaluated the use of losartan in combination with hydrochlorothiazide in those with elevated blood pressure at baseline, and it was found to have a beneficial effect on blood pressure lowering in these patients [ Shahinfar et al. In the hydrochlorothiazide monotherapy group, uric acid levels increased from 8.

Four individuals experienced an acute gouty attack after being switched from losartan back to enalapril therapy. Urate-induced hypertension has been investigated in both experimental and clinical studies. Uricosurix mobile search navigation Article navigation. From a baseline serum uric acid level of 9.

Furthermore, evaluating quality of life and gout attack free intervals would help quantify the relevance of incorporating losartan with xanthine oxidase inhibitors for gout management. Arch Intern Med ; Individuals with secondary hypertension, significant cardiac history including MI within the past year, and transient ischemic attack TIA uricosyric cerebrovascular attack CVA within the past 3 years were excluded.


Humans lack the enzyme uricase, which is responsible for breaking down ingested purines from dietary sources e. Zanchetti A, Mancia G.


All patients carried the wild-type SLC22A12 gene. As urate levels increase, individuals are at a greater risk for saturation and formation of crystals. Shahinfar and colleagues conducted a double-blind, placebo-controlled, parallel study with 63 patients to explore the safety and efficacy of losartan in individuals with thiazide-induced hyperuricemia [ Shahinfar et al.

Conflict of interest statement: This represented an additional Uricosuric medications drugs are substances that increase the excretion uricosurc uric acid in the urinethus reducing the concentration of uric acid in blood plasma. Angiotensin II is a vital regulator of homeostasis and is a primary component of the renin-angiotensin system. Am J Med This page was last edited on 21 Augustat The authors declare no conflicts of interest in preparing this article. View large Download slide.

Uricosuric – Wikipedia

Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. Literature review ARB monotherapy Losratan and colleagues conducted an open-label, randomized, controlled, two-parallel group study [ Rayner et al.

In the losartan monotherapy group, uric acid levels decreased from 8. By their mechanism of action, some uricosurics such as probenecid increase the blood plasma concentration of certain other drugs and their metabolic products. Study participants were excluded if they had a diagnosis of gout or renal lithiasis within the last 2 years. The phase before the administration of the drug consisted of a single-clearance period of 30 min. Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.

Those with baseline use of steroids, NSAIDs, allopurinol, colchicine or with renal dysfunction were excluded. Views Read Edit View history. First-line interventions include dietary modifications such as exercise and consuming a low purine diet [ Crittenden and Pillinger, ; Khanna et al. J Am Soc Nephrol ;9: Many medication therapies have secondary uricosuric effects, and although used for alternate primary indications, can assist conventional agents in reducing serum uric acid levels.


The efffect of serum uric acid on cardiovascular outcomes in the LIFE study. There were no statistical differences in the baseline values of Scr 0.

Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.

Drugs used for gout M This is thought to occur by inhibition of the URAT1 anion exchanger responsible for the reabsorption of filtered urate, which is located in the proximal tubule uricossuric the kidney [ Choi et al.

Antiuricosuric drugs raise serum uric acid levels and lower urine uric acid levels. Receive exclusive offers and updates from Oxford Academic. Please review our privacy policy.

Uricosuric effect of losartan in patients with renal transplants.

J Clin Hypertens Two-way analysis of variance with repeated measures was performed to analyze the effects of losartan and candesartan. Because changes in renal excretion of urate induced by angiotensin receptor blockers might be influenced uricosuirc renal adaptation during their administration, we reexamined the acute effects of candesartan before and 2 h after its administration on renal excretion of urate. Some duplicate citations were included in these results and were removed by comparing each result against the prespecified inclusion and exclusion criteria.