Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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Feeding difficulties and frequent respiratory infections during infancy, diminished muscle tone hypotoniaabnormal looseness laxity of the joints, delayed bone age, developmental delays, hearing loss, and intellectual disability may also be present.

This case report presents an 8-year-old child born to an epileptic mother with a history of AED therapy, with features suggestive of FHS. Treatment may require the coordinated efforts of a team of specialists. Years Published, Fetal alcohol syndrome FAS is a characteristic pattern of mental and physical birth defects that results due to maternal use of alcohol during pregnancy.

Some infants may have increased hair on the body and face. The range and severity of associated abnormalities will vary greatly from one infant to another.

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For information about clinical trials conducted in Europe, contact: Fetal alcohol spectrum disorder. Prevention It is recommended that women be treated with a single anticonvulsant prior to fetl and throughout pregnancy, since it appears that children exposed to multiple anticonvulsants may be at a greater risk for significant birth defects.

Fetal hydantoin syndrome

There have been reports in the medical literature that women with mutations in the methylenetetrahydrofolate reductase MTHFR gene are at an increased risk of synxrome an infant with fetal hydantoin syndrome. From Wikipedia, the free encyclopedia. A teratogen is a drug that interferes with the development of a fetus.


Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years NEAD study: Comparisons may be useful for a differential diagnosis.

The fetal hydantoin syndrome. An increased number of syndorme arches have also been noted. The specific symptoms and severity can vary among affected individuals.

Fetal Hydantoin Syndrome

Case Rep Anesthesiol ; For information about clinical trials sponsored by private sources, contact: D ICD – Specialised Social Services Eurordis hydntoin. Heart defects and cleft lip [3] may also be featured. Manifestations include dysmorphic craniofacial features, hypoplastic distal phalanges and nails, growth delay and delayed psychomotor development.

As affected children grow older, the developmental delays improve, but studies suggest that children may remain slightly behind unexposed siblings. Chronic developmental exposure to phenytoin has long-term behavioral consequences. Phenytoin is often given with other anti-seizure drugs and other adjunct medications that may influence development of the disorder.

Churchill Livingston Elsevier; Anti-seizure medications, also known as antiepileptic or anticonvulsant medications are among the most common teratogens prescribed to women of childbearing age. Related Disorders Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome. Views Read Edit View history. The range and severity of associated abnormalities may vary greatly from one infant to another.

These intermediate metabolites are free radicals that bind to DNA, proteins and lipids adversely affecting neurodevelopment. Infobox medical condition new Articles to be expanded from March All articles to be expanded Articles with empty sections from March All articles with empty sections Articles using small message boxes. These images are a random sampling from a Bing search on the term “Fetal Hydantoin Syndrome. Researchers believe the disease can be transmitted genetically as an autosomal dominant trait but most cases appear to be the result of a new mutation.


Buehler BA, Finnell R. Cleft palate may be repaired by surgery or covered by an artificial device prosthesis that closes or blocks the opening. Additional symptoms occurring with varying frequencies have been reported in the medical literature including congenital heart defects, cardiac rhythm disturbances, behavioral abnormalities such as attention deficit hyperactivity disorder, ocular defects including nearsightedness myopiajoint laxity, kidney abnormalities, and inguinal and umbilical hernia.

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.

Biochemical and molecular teratology of ssyndrome hydantoin syndrome. Also, it is recommended that women taking phenytoin take folic acid supplements, both before conception and during pregnancy as a preventive measure against malformations. Studies have indicated that fetal valproate syndrome is associated with greater risk of neurological and cognitive abnormalities than other anti-seizure medications.

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