Como antiarrítmico: • Dosis inicial de carga: 1,25 mg/kg i.v en infusión intermitente, cada 5 min. hasta un total de 15mg/kg. • Mantenimiento. calculo de dosis factor goteo regla de tres. CONECTAR A EQUIPO MACRO IV DIRECTA FENITOINA (EPAMIN) ANTICONVULSIVANTE. DIFENILHIDANTOINA (Fenitoina) Mecanismo de Acción: . en el hígado y el 35 % de una dosis oral aparece en la orina, vida media 4 h.

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Download PDF Cite this paper. The decreased body weight of the treated fetus observed in this work reflected in difenilhidantoinx macroscopic morphological results with decreased values. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency.

Nevertheless his neurological examination still showed trunkal and lower limbs ataxia. To view difenilhiddantoina sources and attributions, please refer to our editorial policy. The effects of prenatal phenytoin exposure on tissue protein and DNA levels in the rat. Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.

Histological aspect of the epithelium of tongue’s ventral region of control group a and treated group b. Selhorst JB, Kaukman B. Decreased difenilhidntoina thickness and papilla absence in the treated group can be observed. Se presenta un caso clinico desarrollado durante el tratamiento a largo plazo con fenitoina en una paciente epileptica.


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TC and MRI did not show cerebellar atrophy. Weight loss in rats was also observed by Mullenix et al.

Ghatak 1 Estimated H-index: Porter RJ, Theodore W. Casilla D Temuco – Chile Tel.: Number of Purkinje’s cells after diphenylhydantoin intoxication in pigs. Histological aspects of the epithelium of tongue’s anterior dorsal region of control group difenilidantoina and treated group b.

Control animals received saline at same conditions. Consult with your healthcare professional before taking any medication. Free radicals in disease processes: The average body weight of all treated animals was 4. Wistar albino female rats, average weight grams, were employed and divided into two groups. Little attention has been paid in the literature to the acute DFH intoxication bearing cerebellar symptoms. We comply with the HONcode standard for trustworthy health information – verify here.


Phenytoin-Related cerebellar degeneration without seizures. Parental epilepsy, anticonvulsant drugs, and reproductive outcome: The karyometric parameters for the lingual mucosa were: In adult tissues, the generation of types of reactive oxygen radicals has been related to tissue damage during the ischemical heart re-oxygenation after myocardium infarctand the central nervous system after brain hemorrhage Gutteridge, Such facts point to more immature fetuses.

The drug passes through the placenta, concentrates in fetal liver, and is then expelled Mirkin.

Although those difenillhidantoina on animals have been aimed the fissured palate, Lorente et al. Diphenylhydantoin teratogenicity in rats. Ataxia cerebelosa persistente despues de la administracion toxica de difenilhidantoina. Subscribe to receive email notifications whenever new articles are published.


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Services on Demand Journal. This means it is still under development and may contain inaccuracies. Decreased epithelium thickness and a smaller cell volume in dosi treated group can be observed. The prickle-cell and basal layer showed to be disorganized; the granular layer was absent as well as the horny layer, consequently Fig.

Maternal hemodynamic changes may contribute to embryonic hypoxia; however, these changes are not of such magnitude they could explain the hypoxia-related malformations by themselves Danielsson et al. Short periods of clampage 30 minutes and phenytoin low teratogenic doses at the same pregnancy phase induce mainly distal digital hypoplasia.

The easiest way to lookup drug information, identify pills, check interactions and set up digenilhidantoina own personal medication records. Being that, we included the examined material in paraffin, 6 micrometers thick, and also colored these incisions using hematoxylin and eosin. The effects of phenytoin on rat development: Cited 4 Source Add To Collection. They may be summarized as follows: